If you have SU/root, or build your own system.img you can use a hosts file to kill 99.9% of all in-app ads or apparently Adblock Plus has this feature too. The only time my hosts file failed was some simple weather app that refused to work when it detected no access to it's ad server so I rewrote it myself.
If you don't have root you can build your own VPN that can kill all ad traffic, a service that offers this must exist somewhere. If this all sounds too complicated buy an iPhone until Android enables an easy way to kill annoying mobile ads.
Another option is to use something like AdFree Android which includes a hosts file/blacklist that is frequently updated if you don't feel like making your own.
If you don't have root you can build your own VPN that can kill all ad traffic, a service that offers this must exist somewhere. If this all sounds too complicated buy an iPhone until Android enables an easy way to kill annoying mobile ads.