It can be really hard to even get diagnosed with dysautonomia, and absolutely it's hard to treat. A total zoo of seemingly unrelated symptoms made all the more difficult with things like brain fog and psychological impairments.
Interesting, pirenzepine is a antimuscarinic agent (M1 selective antagonist). Neatly in the class of psychopharmacological drugs.
I predominately use Amitriptyline and Modafinil as well as Low Dose Naltrexone (LDN) and a very strict diet. Modafinil is a no-go for anyone with gut issues and I don't know the alternatives very well. Modafinil in the morning and Amitriptyline at night help push my autonomic system into the sympathetic and parasympathetic states respectively. I have a very complicated rational around choosing these meds which is not fully fleshed out yet, but they worked for me and work for some others in the long covid cohort. So for now it is good enough and what I'm sticking with. As I understand the science better I might consider switching up the meds and seeing what happens. I still get PEM and would love to be able to fix that.
Interesting, pirenzepine is a antimuscarinic agent (M1 selective antagonist). Neatly in the class of psychopharmacological drugs.
I predominately use Amitriptyline and Modafinil as well as Low Dose Naltrexone (LDN) and a very strict diet. Modafinil is a no-go for anyone with gut issues and I don't know the alternatives very well. Modafinil in the morning and Amitriptyline at night help push my autonomic system into the sympathetic and parasympathetic states respectively. I have a very complicated rational around choosing these meds which is not fully fleshed out yet, but they worked for me and work for some others in the long covid cohort. So for now it is good enough and what I'm sticking with. As I understand the science better I might consider switching up the meds and seeing what happens. I still get PEM and would love to be able to fix that.