> Although I'm not all that keen on psychedelics and disassociatives, I've tried at least 13 antidepressants and only 1 of them has done anything. The only one that's worked has been mirtazapine* with the caveats of partial GI paralysis and major weight gain. I was on it for 9 years. I tried others as my cognitive faculties and alertness have been declining over the past 2 years.
I’m also on mirtazapine and have been for a few years. It’s the first antidepressant I tried and the doc choose it because I also have insomnia and anxiety. It’s worked well for all three conditions so I’m happy with it. Are you saying you thought it was causing cognitive decline and that’s why you tried others? Wondering if it’s something I should look out for. I can understand the concern because
diphenhydramine has been associated with dementia, and it’s an antihistamine like mirtazapine. However, I read that the anticholinergic property of diphenhydramine was thought to be implicated here, and mirtazapine is not anticholinergic.
I actually used diphenhydramine nightly as a sleep aid for a few years while I was in college until a doctor told me to stop, long before I ever talked to a psychiatrist. Oops. It’s probably not a coincidence I ended up on mirtazapine.
I’m also on mirtazapine and have been for a few years. It’s the first antidepressant I tried and the doc choose it because I also have insomnia and anxiety. It’s worked well for all three conditions so I’m happy with it. Are you saying you thought it was causing cognitive decline and that’s why you tried others? Wondering if it’s something I should look out for. I can understand the concern because diphenhydramine has been associated with dementia, and it’s an antihistamine like mirtazapine. However, I read that the anticholinergic property of diphenhydramine was thought to be implicated here, and mirtazapine is not anticholinergic.
I actually used diphenhydramine nightly as a sleep aid for a few years while I was in college until a doctor told me to stop, long before I ever talked to a psychiatrist. Oops. It’s probably not a coincidence I ended up on mirtazapine.